SPRTN and progeroid features-hepatocellular carcinoma predisposition syndrome: We hypothesized that the decreased velocity of DNA replication forks in SPRTN-depleted or RJALS cells in the presence of DPC-inducing agents leads to prolonged stalling of replisomes and consequently to DNA replication fork collapse, visualized as DNA ds breaks (DSBs), a phenotype observed in RJALS patients (Lessel et al., 2014).