EPB41L5 and tongue squamous cell carcinoma: Given the fact that the high expression of EPB41L5 in primary tongue SCC s tightly correlates with poor outcome of the patient, it is likely that the cancer mesenchymal programs, that lead to the EPB41L5 expression as a result of inducing EMT, is more crucial than the EPB41L5 expression itself in promoting malignancies of tongue SCC.