Tongue SCC patients, having been subjected to the curative resection of primary sites (Table 1), were classified into two groups based on the presence (positive) or the absence (negative) of lymph node metastasis; and EPB41L5 protein expression at the primary lesions were evaluated by the H-score (Fig. 1a). This evidence concerns the gene EPB41L5 and metastatic malignant neoplasm in the lymph nodes.