Considering the high expression of 5-HT and 5-HT7 receptors in TNBC and 5-HT-induced angiogenesis, we believe the suppression of 5-HT signaling linked to breast cancer progression and endothelial responses by using BJ-1113 constitutes a novel approach to cancer therapy against drug-resistant breast cancer growth and metastasis. The gene discussed is HTR5A; the disease is breast cancer.