NC-ADPKD cells have higher-than-normal and C-ADPKD cells have lower-than-normal expression of KCNN4 (potassium calcium-activated channel subfamily N member 4), KCNV1 (potassium voltage gated channel modifier subfamily V member 1), and KCNS3 (potassium voltage-gated channel subfamily A member 3). This evidence concerns the gene KCNS3 and nevus comedonicus syndrome.