This study aimed to further explore the effects of connexin50 mutation on metabolic and cytokine profile in SHR-Dca−/− and SHR-Dca+/− strains including a battery of parameters of oxidative stress in the animals challenged by dexamethasone, a dyslipidemia and insulin resistance-inducing glucocorticoid [11, 12]. This evidence concerns the gene INS and metabolic syndrome.