Considering the rapid induction of pro-inflammatory COX-2 and prostaglandins in the brains of AD patients [6, 11], we have previously reported the effect of PGE2 on the phagocytic ability of fAβ42-stimulated N9 cells and demonstrated a significant decrease in fAβ42-activated microglial phagocytosis of fluorescent-labeled latex beads by PGE2 [18]. The gene discussed is PTGS2; the disease is Alzheimer disease.