However, as a peculiarity of the tumor advancing edge, where small groups or cords of infiltrating tumor cells were present, the staining pattern became also cytoplasmic for all cadherins, Integrin β1 and Beta-catenin (Fig. 3d), and even nuclear for N- (Fig. 3e) and P-cadherin. The gene discussed is CTNNB1; the disease is neoplasm.