Thus, we observed expression of matrix metalloproteinases (MMP)-1, MMP-2, MMP-3, and MMP-9 mainly in the nuclei of tumor cells, while for MMP-3 and MMP-9 the immunoreactivity was also present in the cytoplasm of tumor cells and in the amyloid deposits (Fig. 3a, b). Here, MMP1 is linked to neoplasm.