Hirakawa at al. reported that the MST for patients with curatively resected pancreatic cancer associated with HER3 overexpression was 37.2 months, while that for HER3-negative patients was 58.6 months (P = 0.008) [20], the findings was similar to those of our study; our Cox’s regression analysis demonstrated that the risk of death associated with HER3 positive expression was 3.684 fold greater than that associated with HER3 negative expression. This evidence concerns the gene ERBB3 and familial pancreatic carcinoma.