These events are nuclear fusion for gestational trophoblast tumors, meiosis for germ cell tumours, VDJ recombination for ALL and anaplastic lymphoma kinase (ALK) + ve T cell NHL, somatic hypermutation (SHM) for DLBCL, Hodgkin’s disease and Burkitt’s lymphoma and gastrulation for the rare childhood malignancies. Here, ALK is linked to acute lymphoblastic leukemia.