Interestingly, genetic polymorphisms implicated in central profibrotic and inflammatory pathways such as SNPs of the angiotensin-converting enzyme gene (ACE), [16] the angiotensinogen gene (AGT) [17] or the interleukin-6 receptor gene (IL6R) [18] have also been found to predict recurring atrial arrhythmias after AF ablation. This evidence concerns the gene ACE and atrial fibrillation.