Lack of regular exercise was associated with significantly higher mean fasting insulin (difference in means = 2.3 mU/L; 95% CI, 0.5 to 4.1) and HOMA-IR (difference in means = 0.49; 95% CI, 0.09 to 0.90) levels but not with the risk of insulin resistance, after adjusting for potential confounders and the other lifestyle factors (shift work and sleep length). The gene discussed is INS; the disease is Insulin resistance.