MKI67 and urinary bladder neoplasm: Additionally, after intravesical chemotherapy, the incidence rates of UTUC recurrence in the bladder decreased more in the low-level Ki-67 sub-groups than in the high-level Ki-67 sub-groups (Fig 3B, P = 0.025), and a synergistic biological interaction was observed between low-level Ki-67 labeling and without intravesical chemotherapy in leading to bladder tumor recurrence (Fig 3B, S = 3.118, AP = 0.598).