Regarding the pre-therapy levels of all the patients, the univariate and multivariate analyses showed that uric acid and HDL-C were independently associated with sex; HDL-C, C3, and hepatic steatosis were independently associated with BMI; and BMI, TC, C4, and the IFNL3-rs12979860 CC genotype were independently associated with the C3 level. The gene discussed is IFNL3; the disease is Hepatic steatosis.