In this study, we identified multiple gene expression and pathway activation markers specific for the AML (Table 1), among them seven genes (CAMK2B, EIF4B, HAPLN1, HIST1H3B, LIPE, MAPK13, SAR1B) and one pathway (branch of Inositol-3-phosphate signaling pathway responsible for gene expression with the transcriptional factors CREB3, NFATC2 and MEF2D), for which association with the AML was previously unknown. Here, H3C4 is linked to acute myeloid leukemia.