Overall, the top expression biomarkers for the pediatric and adult AML were not highly overlapping, thus producing only two completely matching commonly regulated top pathways: a branch of the CD40 pathway influencing cell survival, and a branch of the Ras pathway affecting CDC42 pathway, which were commonly downregulated and upregulated, respectively, in both types of AML. This evidence concerns the gene CD40 and acute myeloid leukemia.