Among the top AML-specific pathways for the groups of adult and pediatric cancers, we identified only three (~9%) completely matching molecular pathways, of which two were commonly regulated (a branch of the CD40 pathway, and a branch of the Ras pathway), and one (a branch of the ATM Pathway governing control over the cell cycle checkpoints) was regulated oppositely, being upregulated in children and downregulated in the adults (Table 2). The gene discussed is CD40; the disease is acute myeloid leukemia.