In particular, animal models of CNM linked to MTM1 deficiency show disorganization of the T-tubule system, reduction in Ca2+ release from the SR, and ECC defect without change in basal cytosolic calcium concentration (Al-Qusairi et al., 2009; Dowling et al., 2009), in agreement with MTM1 and BIN1 expression at the T-tubule system (Buj-Bello et al., 2008; Dowling et al., 2009; Lee et al., 2002; Razzaq et al., 2001; Tjondrokoesoemo et al., 2011). The gene discussed is BIN1; the disease is centronuclear myopathy.