One central question for the DNM2-related diseases is to understand why mutations of the ubiquitously expressed DNM2 lead to a tissue-specific phenotype only affecting skeletal muscles in AD-CNM (Bitoun et al., 2005) or peripheral nervous system in rare form of Charcot–Marie–Tooth neuropathy (Zuchner et al., 2005). This evidence concerns the gene DNM2 and Alzheimer disease.