More recent evidence indicates that the SHREW-1/AJAP1 gene is also silenced in other tumor types such as gastric (Matsusaka et al., 2011), cervical (Chen et al., 2014) and endometrial cancer (Lai et al., 2014), or hepatocellular carcinoma (Ezaka et al., 2015). This evidence concerns the gene AJAP1 and hepatocellular carcinoma.