According to these analyses, shrew-1 (also called AJAP1) is a tumor suppressor whose gene becomes hypermethylated and thus epigenetically silenced in the course of tumor development (Chen et al., 2014; Cogdell et al., 2011; Ezaka et al., 2015; Lai et al., 2014). The gene discussed is AJAP1; the disease is neoplasm.