RPS19 and Diamond-Blackfan anemia: As shown in Table 2, Rsp19‐/‐ homozygous mice are embryonic lethal, whilst heterozygous mice either are normal or show a mild macrocytic anemia (depending on the nature of targeted gene event), indicating that these models are unable to truly recapitulate the RPS19 haploinsufficiency described in the human DBA patients.