TP53 and breast carcinoma: It is noteworthy that this p53 inactivation-mediated gain of immunosuppressive function is not restricted to p53 deletion because the mouse model of p53 mutation, which mimics human hotspot p53 mutations, also exemplifies exacerbated tissue inflammation in intestinal epithelial cells, liver, and breast tissues, leading to the development of colon, liver, and breast cancers, respectively [53,54,55].