Interestingly, HTLV-1 infection appears to be associated with increased development of autoimmune diseases, including RA, SS, and systemic lupus erythematosus (SLE) [85], although it is yet to be determined whether this HTLV-1-induced chronic inflammation is at least partially resulted by p53 dysfunction in immune cells. The gene discussed is TP53; the disease is rheumatoid arthritis.