It has been shown that overexpression of the natural p53 inhibitory protein mouse double minute 2 homolog (MDM2) or expression of certain viral proteins upon viral infection, such as human papillomavirus (HPV) E6 and human T-lymphotropic virus 1 (HLTV-1), also lead to inhibition of p53 activity, which has been linked to tumorigenesis [81,82,83,84]. The gene discussed is TP53; the disease is viral infectious disease.