AKT1 and central nervous system cancer: In comparison to p38MAPK inactivation in hippocampal neurons [24,25], overexpression of CAPON-S remarkably suppressed the phosphorylation of Akt (Thr308 and Ser473) and S6 (Ser235/236), in glioma cells, without affecting any signaling molecule in the MAPK pathway (Table S1).