Follicular stimulating hormone (FSH) has been shown to be increased [36,39,45], with one study suggesting that this is mainly the case for PMCs between 30 and 39 years of age [24]; the latter study also suggested that anti-müllerian hormone (AMH) may be a more sensitive measure of ovarian dysfunction in PMCs as significant differences in AMH existed across all age groups. This evidence concerns the gene BRD2 and ovarian dysfunction.