Other mechanisms of apoptosis by RE include enhanced protein expression of pro-apoptotic Bax and cleaved-caspase 3 [23,33], increased expression of binding immunoglobulin protein (BiP) and CCAAT/-enhancer-binding protein homologous protein (CHOP) proteins which induce endoplasmic reticular stress [25,33], and the unfolded protein response [24,25,26,33] in prostate and colon cancer cells. This evidence concerns the gene HSPA5 and malignant colon neoplasm.