HMOX1 and malignant colon neoplasm: The Nrf2/antioxidant response element (ARE) signaling pathway has been considered to protect cells against carcinogenesis and attenuate cancer development by neutralizing ROS and carcinogens and members of this pathway, including sestrin-2 and heme oxygenase-1 (HO-1), are upregulated by RE in colon cancer cells [23,25].