Serum samples from mice xenografted with prostate cancer cells and fed RE in their diet showed a decrease in prostate-specific antigen (PSA) levels (high levels would be suggestive of prostate cancer) and examination of tissue samples showed decreased androgen receptor and CHOP expression, indicative of an induction of apoptosis associated with endoplasmic reticular stress [33]. This evidence concerns the gene KLK3 and Familial prostate cancer.