Induction of apoptosis by endoplasmic reticular stress has been found by several studies in colon cancer cells [19,23,24,26] and has been shown to involve translocation of nuclear factor erythroid 2-related factor 2 (Nrf2) into the nucleus and induction of p38 MAPK and PERK activity. Here, NFE2L2 is linked to colonic neoplasm.