The important factors of DM diseases are a family history of DM, age, obesity, impaired glucose tolerance, gestational diabetes, and chronic hypo-glycaemia and hyper-glycaemia with disturbances in the metabolism of carbohydrates, fats and proteins resulting from defects in insulin secretion, insulin action or both [1,2]. Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.