Apremilast is a small‐molecule (nonbiologic) oral phosphodiesterase 4 (PDE4) inhibitor that works intracellularly to regulate production of pro‐ and anti‐inflammatory mediators implicated in the pathogenesis of psoriasis and psoriatic arthritis (Schafer et al., 2010). The gene discussed is PDE4A; the disease is psoriatic arthritis.