RUNX1 and acute lymphoblastic leukemia: Although a small proportion of primary human T‐cell acute lymphoblastic leukemias (ALL) carry point mutations in RUNX1 [Grossmann et al., 2011], evidence for an oncogenic role for this gene in childhood B‐ALL is suggested by the high expression of RUNX1 [Niini et al., 2000] and high level amplification in a poor prognosis subset [Robinson et al., 2003].