Moreover, in a series of studies performed in a CPC-APC mouse model of colon cancer, several researchers have demonstrated that manipulations in the biological activity of IL-17/IL-23 (gene disruption, receptor ablation, or neutralization using specific antibodies) inhibit colonic tumor development due to decreases in cell proliferation, as well as preventing progression from adenoma to carcinoma18, 19, 20. Here, IL17A is linked to malignant colon neoplasm.