IL17A and colonic neoplasm: Moreover, in a series of studies performed in a CPC-APC mouse model of colon cancer, several researchers have demonstrated that manipulations in the biological activity of IL-17/IL-23 (gene disruption, receptor ablation, or neutralization using specific antibodies) inhibit colonic tumor development due to decreases in cell proliferation, as well as preventing progression from adenoma to carcinoma18, 19, 20.