We re-analyzed these 4 candidate genes in a replication cohort of 15 IPF subjects (8-progressive and 7-stable) and observed an even greater decrease in FGF-10 (−3.77 Log2-fold change; p < 0.04) in IPF subjects with progressive disease; the other developmental genes of interest showed similar trends to the discovery cohort, although statistical significance was not achieved. The gene discussed is FGF10; the disease is idiopathic pulmonary fibrosis.