SOX2 and breast adenocarcinoma: Indeed, we found an enrichment of TICs in mammary adenocarcinomas from TAp63−/− mice by IF using markers for MaSCs (Slug, Sox9, Sox2 and ALDH) (Figures 3o–q and t–v and Supplementary Figures S6a–r and y–a') and an upregulation of the mesenchymal marker, vimentin (Figures 3r and w and Supplementary Figures S6s–x and b'), with a concomitant downregulation of the epithelial marker, E-cadherin (Figures 3s–x), demonstrating EMT in these tumors and suggesting that cells characterized are TICs.