Furthermore, the contribution of KDM4B to the formation and growth of tumor spheroids in vitro likely relates to in vivo function of KDM4B by facilitating peritoneal seeding.4 These phenotypes appear to be distinct from the actions of KDM4A in EOC and other cancers, where it promotes copy number gain and drug resistance.23, 24. Here, KDM4B is linked to neoplasm.