LCN2 and ovarian cancer: Considering the large number of genes dependent on KDM4B in SKOV3ip.1 cells, it is unclear which specific genes or pathways are primarily responsible for mediating metastasis, although LCN2, LOX, LOXL2 and PDGFB make compelling candidates with proven abilities to influence either ovarian cancer growth or general metastasis.17, 19, 29, 30 Analysis of data sets curated by Gyorffy et al.20 demonstrated that elevated LOX expression in tumor samples correlated with reduced progression-free survival in EOC (Figure 3e).