In hormone-dependent breast and prostate cancers, KDM4B is both a target and facilitator of hormone-dependent transcription.25, 26 In colon and gastric cancers, KDM4B regulates β-catenin-dependent gene expression to promote attachment-free growth and metastatic behavior.27, 28 In EOC, although KDM4B regulates distinct sets of genes in different oxygen tensions, invasive and migratory behaviors are the most robust phenotypes (Figures 3, 4, 5, 6). This evidence concerns the gene KDM4B and gastric cancer.