2003). Furthermore, combined blockade of VEGFR2 and Tie2 led to a greater inhibition of tumour angiogenesis than either factor alone (Jendreyko et al. 2005). These results therefore support the recent findings that double blockade of Ang and VEGF signalling may be more effective than either alone (Koh et al. 2010). The gene discussed is TEK; the disease is neoplasm.