Additionally, levels of the phosphorylated cyclic AMP-response element binding protein, as well as its upstream sensors, CD114 and receptor for advanced glycation endproducts, and downstream targets, CD39 and CXCR4, which function together as another anabolic switch in cells, were found to be increased in CF airway neutrophils [32]. The gene discussed is CXCR4; the disease is cystic fibrosis.