The main mechanism in this process was that vascular endothelial growth factor (VEGF) and interleukin- (IL-) 10 in tumor microenvironment downregulated the expression of major histocompatibility complex (MHC) II and costimulators on DCs by activating signal transducer and activator of transcription (STAT) 3 signaling [15, 16]. Here, VEGFA is linked to neoplasm.