To investigate the effects of AQP3 on chemosensitivity in GC cells, its expression was upregulated in AGS cells and downregulated in MGC803 and SGC7901 cells by lentiviral transduction, as previously reported (Figure 1b).12,13 AQP3 overexpression induced cDDP resistance compared with control AGS cells (P<0.05, Figure 1c), and AQP3 knockdown increased the chemosensitivity of MGC803 and SGC7901 cells (P<0.05, Figure 1c). The gene discussed is AQP3; the disease is gastric cancer.