Gao et al.14 showed that AQP3 inhibits the therapeutic effect of arsenite in melanoma by upregulating expression of the anti-apoptotic genes Bcl-2 and XIAP, while concurrently downregulating expression of the pro-apoptotic genes P53 and BAX. We demonstrated in this study that AQP3 enhances autophagy in gastric cancer cells. This evidence concerns the gene TP53 and gastric cancer.