In conclusion, our data show that AQP3 facilitates chemoresistance in GC cells to cDDP, suggesting that the development of AQP3-based tumor therapeutics could enhance the efficacy of cDDP in GC.10 Further studies are needed to investigate the molecular details of AQP3-induced autophagy and the other potential mechanisms underlying AQP3-induced chemoresistance. Here, AQP3 is linked to gastric cancer.