NANOG and posterior cortical atrophy: As the FOXA consensus sequence is the top binding motif for NANOG in PCa cells, and because rhNANOG protein has the potential to more strongly bind the FOXA1 genomic motif and can further interact directly with both AR and FOXA1, we speculate that NANOG may be recruited to AR and/or FOXA1 sites by preferentially binding to some forkhead response elements (FKHREs) and, either alternatively or perhaps simultaneously, by interacting with AR and FOXA1 proteins (Figure 7e).