Indeed, NANOG knockdown inhibits sphere formation, clonal growth, cell proliferation and tumor regeneration in breast, colon and prostate cancer cells [3] and NANOG knockdown in the undifferentiated, self-renewing and castration-resistant PSA−/lo LAPC9 PCa cells inhibits tumor regeneration in androgen-deficient hosts [11]. This evidence concerns the gene NANOG and neoplasm.