Among the 806 NANOG1 and NP8 commonly occupied promoters in LNCaP cells were many developmentally related genes including HOXA3 and A4; HOXC4 and C9; LIN7A, 7C and 37; DICER1, NOTCH1, HES6, GLI3 and TBX3; chromatin remodeling and epigenetic regulators important for SC functions such as KDM4A, 4B and 4D; CITED2, PHF8, ARID1A and ARID5A; TRIM68 and PRMT3/8; and molecules implicated in CSCs (for example, CD44 and KLF5) and PCa development (for example, TPD52 ; Figure 2c and d; Supplementary Figure S2A and B). This evidence concerns the gene KLF5 and posterior cortical atrophy.