Interestingly, ChIP–qPCR analysis of CDK1 genomic binding (Supplementary Figure S8A;, Supplementary Figure S2C) detected NANOG binding, nearly equally, to the three enhancers of the CDK1 gene in AD cells (Figure 7b) but, strikingly, NANOG binding to enhancer 3 was greatly increased in AI cells (Figure 7c). This evidence concerns the gene NANOG and Alzheimer disease.