Indeed, NANOG knockdown inhibits sphere formation, clonal growth, cell proliferation and tumor regeneration in breast, colon and prostate cancer cells [3] and NANOG knockdown in the undifferentiated, self-renewing and castration-resistant PSA−/lo LAPC9 PCa cells inhibits tumor regeneration in androgen-deficient hosts [11]. The gene discussed is NANOG; the disease is Familial prostate cancer.