GO analysis of distal chromatin (defined by the −8 kb to +2 kb promoter region plus a 200 kb extension in both directions) occupancy by GREAT (Gene Region Enrichment and Annotation Tool [17]) revealed an association with PCa, CSC traits and steroid hormone receptor signaling (Figure 2f) including AR-responsive (both up- and downregulated) genes such as KLK3, CDK1, NKX3.1, TPD52, TMPRSS2, LRIG1 and SOX9 (Supplementary Figure S2C). This evidence concerns the gene NKX3-1 and posterior cortical atrophy.