Another study showed CD152 autoantibody to be absent from healthy individuals but present at high concentrations in patients with several autoimmune diseases.24 The present of anti-lymphocyte autoantibodies has been demonstrated in systemic lupus erythematosus,25 HIV infection26 and rheumatoid arthritis.27 It is here confirmed the present of another autoantibody to CD80. The gene discussed is CTLA4; the disease is systemic lupus erythematosus.