Results showed that the serum levels of IL-6 and IL-8 in COPD were closely associated with the titers of auto-antibodies to rs1CD80 (r=0.797, P<0.001 and r=0.608, P<0.001, respectively) (Figures 3a and b). The gene discussed is CXCL8; the disease is chronic obstructive pulmonary disease.