Another study showed CD152 autoantibody to be absent from healthy individuals but present at high concentrations in patients with several autoimmune diseases.24 The present of anti-lymphocyte autoantibodies has been demonstrated in systemic lupus erythematosus,25 HIV infection26 and rheumatoid arthritis.27 It is here confirmed the present of another autoantibody to CD80. This evidence concerns the gene CTLA4 and autoimmune disease.