Despite studies that have demonstrated that NLRP3 contributes to renal ischemia reperfusion (I/R) injury by a direct effect on renal tubular epithelium [17, 18], it remains unclear how NLRP3 is able to sense redox changes, particularly in renal tubular epithelium during ischemia AKI in diabetes. Here, NLRP3 is linked to diabetes mellitus.