Moreover, RES treatment attenuated NLRP3 inflammasome protein activation at 48 hours after ischemia in DM rats while concomitantly reducing the expression of caspase-1 and release of IL-1β and IL-18 (Figures 4(b), 4(d), and 4(f)–4(h)). This evidence concerns the gene CASP1 and diabetes mellitus.