Recombinant human GH therapy was first approved for children with GHD in 1985 and later for the treatment of various conditions like idiopathic short stature (ISS), Turner syndrome (TS), Noonan syndrome (NS), Prader-Willi syndrome (PWS), chronic renal failure (CRF), and small for gestational age (SGA) [19–21]. The gene discussed is GH1; the disease is Prader-Willi syndrome.