While it is still not entirely clear why some mutations in the SWI/SNF complex predispose to cancer, while others lead to intellectual disability, but it has been postulated that the mutations in any of the SWI/SNF complex members that lead to developmental disorders exert either dominant-negative or gain-of-function effects, while those leading to SCCOHT are loss-of-function mutations [10]. Here, SMARCA1 is linked to cancer.