IDE and Alzheimer disease: Furthermore, the study provided proof that T2DM and AD aggravate each other and suggested several potential mechanisms underlying the two disorders, such as, Aβ clearance by insulin degradation enzyme (IDE), glucose metabolism, O-GlcNAcylation, Aβ aggregation by advanced glycation end products (AGEs), oxidative stress, circulating cortisol, and cerebral vascular insufficiency, as well as inflammation, and aging.