SNCA and Parkinson disease: A wide variety of studies have shown that changes in mitochondrial trafficking are the earliest events to occur in cell models for Parkinson’s disease with abnormal α-synuclein expression (Coskun et al. 2012; Prots et al. 2013; Arduino et al. 2015; Keogh and Chinnery 2015; Franco-Iborra et al. 2016).