CD4 and HIV infectious disease: To better understand the specific qualitative and quantitative deficits affecting immunity in latent TB during HIV infection, we compared the magnitude, functional and memory profiles of CD4+ T cell responses to distinct mycobacterial antigens (ESAT-6/CFP-10 peptide pool, purified protein derivative (PPD) or Bacille Calmette Guérin (BCG)) in HIV-uninfected individuals and antiretroviral therapy naïve HIV-infected individuals with well-preserved CD4 counts.