Five monogenic diabetes risk genes (Supplemental Table S11; Hoffmann and Spengler 2012; Senniappan et al. 2013; Schwitzgebel 2014), were enriched in beta cells (i.e., greater than fourfold change in expression in specific islet cell type relative to other endocrine cells), including glucose transporter SLC2A2 (data not shown), beta cell maturation transcription factor PDX1, and the sulfonylurea drug target ABCC8 (Fig. 4C). Here, ABCC8 is linked to diabetes mellitus.