Soluble CD36 is a biomarker of T2D (Alkhatatbeh et al. 2013) and diabetic nephropathy (Shiju et al. 2015) and coordinates activation of the NLRP3 inflammasome, leading to proinflammatory cytokine release and reduced insulin secretion (Sheedy et al. 2013). Here, NLRP3 is linked to type 2 diabetes mellitus.