Gene set enrichment analysis (GSEA) identified enrichment (FDR-adjusted P-value <0.05) of insulin signaling, oxidative phosphorylation, maturity-onset diabetes of the young (MODY), and glycolysis/gluconeogenesis KEGG pathways in beta cells relative to the other endocrine cells (Supplemental Table S8). The gene discussed is INS; the disease is type 2 diabetes mellitus.