The clonal expansion frequencies of the TRDV2 and TRDV4 subfamilies were significantly higher than those in healthy individuals (P = 0.012 and P = 0.009); however, a significantly lower clonal expansion frequency for TRDV1 was observed in the AML patients (P = 0.046) (Fig. 2b). The gene discussed is TRDV1; the disease is acute myeloid leukemia.