Over 20 years ago, mutations in superoxide dismutase 1 (SOD1) were identified as causative for ALS [24]; however, the recent wave of genetic discoveries in the field has implicated genes such as TAR DNA-binding protein (TARDBP) [28], fused in sarcoma (FUS) [13, 29], and the G4C2 repeat expansion in chromosome 9 open reading frame 72 (C9orf72) [5, 23]. Here, TARDBP is linked to amyotrophic lateral sclerosis.