RIMS4 and neoplasm: The analysis of the tumor revealed 15 somatic acquired mutations, 12 of which were protein-affecting variants (validated by capillary sequencing) including one non-sense mutation in the ZNF808 gene, one nucleotide change at the 3’ splice site of RIMS4, and 10 missense mutations considered disease associated by at least one pathogenicity prediction program (Table 1).