AD patients show abnormal aggregation of beta-amyloids (\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$A_{\beta }^{o}$\end{document}Aβo) and neurofibrillary tangles (NFTs) of hyperphosphorylated tau proteins. This evidence concerns the gene MAPT and Alzheimer disease.