We assume that in AD, 60% of hyperphosphorylated tau proteins (whose concentration in disease is 490 pg/ml [89]) are in NFT form, so that \documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$K_{F_{i}}=0.6\times 490$\end{document}KFi=0.6×490 pg/ml= 2.94×10−10 g/ml. Here, MAPT is linked to Alzheimer disease.