The susceptibility to Prima-1, 3-BrPA and NAC in MelJuso cells (BRAF wild-type (wt) and NRAS-Q61L mutant) [29] was compared with that of C8161 melanoma with an enhancing KRAS G12D mutation and a G464E mutation in the BRAF P loop region [31]. This evidence concerns the gene NRAS and melanoma.