This may explain the lower VEGF expression in 5 mM glucose in hypoxic A549 (Fig. 4c) and MelJuso cells (Fig. 9e), resembling results showing lower VEGF-A transcripts in mouse pancreas beta cells after hypoglycemia [48] No comparable decrease was seen in VEGF or CAIX mRNA expression in hypoxic C8161 cells (Fig. 9f), implying that the response to hypoxia in 5 mM glucose may be tumor cell-dependent. Here, CA9 is linked to neoplasm.