Prima-1Met also has been shown to induce apoptosis in multiple myeloma [9], Ewing sarcoma irrespective of p53 status [10], in human prostate cancer, in a mouse leukemia cell line lacking p53 expression [11] and even in tumor cells lacking p53 through inhibition of thioredoxin reductase I [12]. The gene discussed is TP53; the disease is Ewing sarcoma.