Using multivariable cox regression analysis, ANLN was suggested as an independent prognostic factor for BCSS following adjustment for tumor size, nodal status, tumor grade, hormone receptor status, HER2 status, Ki-67, tumor type, age and the proteins PDZ-Domain Containing 1 (PDZK1) and PDZ-Binding Kinase (PBK). This evidence concerns the gene PBK and neoplasm.