FCRL3 and rheumatoid arthritis: Of the 4 SNPs positively associated with rheumatoid arthritis, FCRL3 -169T>C (marked by rs7528684 in the promoter region of FCRL3) substitution substantially increased promoter activity in FCRL3 and enhanced binding affinity to the consensus NF-κβ binding motif, where NF-κβ widely regulates genes involved in immune response [43].