The strongest evidence linking FCRL3 polymorphisms with autoimmunity is derived from linkage disequilibrium mapping of the chr1q21-23 region in rheumatoid arthritis, which identified 4 SNPs (rs7528684, rs11264799, rs945635 and rs3761959) in a Japanese population [43]. The gene discussed is FCRL3; the disease is rheumatoid arthritis.