Phospholipid remodeling in obesity has been linked to ER stress and disrupted calcium signalling.40 Given that the activities of both LPCAT2 and cPLA2 are calcium‐dependent, further elucidation of the relationships between ER stress, calcium signaling, and lipid remodeling in NAFLD may be warranted. Here, LPCAT2 is linked to metabolic dysfunction-associated steatotic liver disease.