HCN1 and breast carcinoma: For SNP rs981782 in the HCN1 gene, the genotype “G/T” increased clinical stage (UICC) III and IV breast cancer risk by1.83-fold (OR = 1.83; 95% CI, 1.20-2.80; p = 0.063) in the codominant model and “G/T-G/G” genotype in the dominant model (OR = 1.62; 95% CI, 1.08-2.45; p = 0.019) (Supplementary Table S4).